How Epithalon Peptides Fights Aging

Epithalon is a peptide consisting of four amino acids and it is usually found in naturally occurring pineal gland proteins. Through extensive animal research, it has been shown that the peptide is a potent cell metabolism regulator, and this includes cell division and cell growth. In particular, the peptide has the ability to extend the survival of a cell in vitro. The reason why it has such a capability can be related to its actions on telomeres.

How Epithalon Peptides Fights Aging


Telomeres refers to the repetitive nucleotide sequence normally found at the tail end of a linear chromosome. Their main purpose is to protect the DNA strands from deterioration and degeneration. A telomere sequence usually starts at about 11,000 DNA units long, but the sequence reduces to about 4,000, depending on the age. It is interesting to note that the rate at which the telomeres degenerate in men is faster than it does in women.

Epithalon and Telomeres

Telomarase reverse transcriptase is an enzyme known to rebuild telomeres leading to a reduction in the molecular aging of the cells. However, the enzyme is not 100% effective and this allow for aging to take place even in the presence of the enzyme.

A research conducted in 1998 revealed that boosting telomeres artificially may extend the lifespan of human somatic (skin) cells in culture, and this could potentially make them immortal. Since then, researchers have been attempting to boost the activities of telomeres by using metabolic suppression, gene therapy, and hibernation. But all these approaches come with significant drawbacks and none of them have so far been demonstrated to be effective in reducing the effects of aging in human beings.

It was not until 2003 that a study revealed the possibility of epithalon impacting the activities of telomeres in human skin cells in vitro. The study revealed that epithalon could be added to fibroblast culture without any telomeres activity and this could stimulate the production of telomerase. It was noticed that all the cells demonstrated telomere lengthening.

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